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In 2019, it was selected as one of the Best Tools for Data Analytics, Modernization, and Security by NextREAL Customer Awards.
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Category:Programming tools for Windows
Category:Vulnerability assessment
Category:Computer security softwareAssociation of SDHA rs6004 Polymorphism With Risk of Chronic Obstructive Pulmonary Disease and Chronic Obstructive Pulmonary Disease-Related Mortality.
Recent studies have shown that mitochondrial gene mutations may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Genome-wide association studies in large COPD cohorts have identified a large number of candidate genes. The main aim of the study was to assess the association of single nucleotide polymorphisms (SNPs) in genes related to oxidative phosphorylation with COPD and COPD-related mortality in Polish population. The study included 206 COPD patients, recruited by the Polish Research Group on Pulmonary Rehabilitation and Long-Term Follow-up. The control group consisted of 204 healthy individuals. DNA samples were genotyped for an association study of three SNPs (rs6025, rs17849417, and rs6004) in the gene encoding the mitochondrial complex II subunit SDHA. Genotype distributions were compared between the groups using the χ2 test. Mortality caused by COPD was also evaluated by comparing genotypes. The distribution of the polymorphism rs6004 differed significantly between COPD patients and healthy individuals (p = 0.0019). This effect was also observed in the group of COPD patients who had survived more than 10 years from the diagnosis of disease, ie, in patients for whom a long-term follow-up was possible (p = 0.0026). Also, homozygotes of the mutant A allele were associated with higher COPD-related mortality in the group of survivors (p = 0.0098). In conclusion, a SNP in the SDHA gene (rs6004) is associated with COPD and COPD-related mortality. The SNP may influence the development of COPD and mortality in patients in whom long-term survival was possible.World Wide Weddings Review
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