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Apr 28, 2022
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Category:Printing softwareRole of hormone receptor status in resectable early-stage gallbladder adenocarcinoma: analysis of 173 patients.
There is increasing evidence supporting the importance of estrogen receptors (ERs) and progesterone receptors (PRs) as predictive or prognostic factors in several malignant conditions of the digestive tract. Although a few studies have evaluated the role of hormonal receptor expression in gallbladder adenocarcinoma (GA), the results are contradictory. A potential explanation is that hormonal receptors are actually related to the stage of the disease. We aimed to analyze the relationship between hormonal receptor expression and clinicopathological variables in a cohort of patients with resectable early-stage GA. Patients with a preoperative diagnosis of GA by pathologic evaluation (T1-T2 tumors) were retrospectively identified. Consecutive cases with positive estrogen and/or progesterone receptors were included in the study. One hundred seventy-three patients were identified (89 male and 84 female). Eighty-seven (49.7%) tumors were associated with lymph node metastasis and 67 (38.2%) showed hepatic infiltration. Hormone receptor expression was positive in 23 (13%) cases. In the univariate analysis, patients with estrogen and/or progesterone-positive GA showed a favorable prognosis, although the difference was not significant. The presence of lymph node metastasis was associated with worse survival in patients with estrogen or progesterone receptors. On the contrary, hormone receptor expression was not associated with any significant influence in the univariate analysis. In the multivariate analysis, however, lymph node metastasis was the only variable that was a strong predictor of unfavorable overall survival. The data support the hypothesis that the presence of lymph node involvement confers a worse survival in GA. Concerning hormone receptors, this study suggests that they do not appear to be independent prognostic factors in patients with resectable early-stage GA.Additional information

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Multi-in-one media card for Zebra Printers. This media card not only outputs as a card, but also as an independent.
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