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Safety and efficacy of tumour necrosis factor blockade for the treatment of active distal ulcerative colitis: a systematic review and meta-analysis. Inflammatory bowel diseases are characterised by episodic exacerbations and potentially devastating damage to the intestine. In Ulcerative Colitis (UC), tumour necrosis factor (TNF) inhibitors are effective for induction and maintenance of remission, but their safety in patients with clinically active distal UC has not been fully elucidated. Systematic review and meta-analysis of the current literature to determine the safety and efficacy of TNF blockade in patients with distal UC. Electronic searches were conducted using MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials to identify studies of any design that compared patients with UC receiving TNF inhibitors versus patients not treated with TNF inhibitors that reported rates of adverse events or adverse event-related outcomes. We calculated the relative risk (RR) for each outcome of interest. Thirty-seven articles were identified that met inclusion criteria. No significant differences were found in the incidence of serious adverse events (RR 0.99, 95% CI 0.95 to 1.06), symptomatic infections (RR 0.90, 95% CI 0.70 to 1.17), infusion reactions (RR 1.15, 95% CI 0.72 to 1.84), UC flare (RR 1.08, 95% CI 0.69 to 1.70), the need for rescue medication (RR 0.97, 95% CI 0.96 to 1.01) or the rate of adverse event-related withdrawals (RR 1.00, 95% CI 0.94 to 1.06), or endoscopic outcomes (RR 0.92, 95% CI 0.76 to 1.13) between patients receiving TNF inhibitors compared with those not receiving such therapy. Use of TNF inhibitors in patients with distal UC is not associated with an increased risk of adverse events or deterioration in disease activity. Therefore, TNF inhibitors may be considered for the management of patients with clinically active distal UC.An IM-based [L]{.smallcaps}-arginine-to-trans-N-[d]{.smallcaps}-arginine
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How To Crack Elden Ring:
System Requirements:
- OS
- Windows 7/8/10
- Processor
- 2.8 GHz Pentium III or faster
- RAM
- 512 Mb or more
- Video Memory
- 25 Mb or more
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- Online connection
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