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■ Encrypted file format(Reuters Health) – An online treatment program to help smokers quit could reduce the rate of relapse, a new study suggests.

Smoking remains the leading cause of preventable death in the United States, with about 46 million adults smoking cigarettes, cigars or pipe tobacco. And, despite plenty of resources and efforts to stop people from smoking, fewer than half of Americans who are trying to quit succeed by the end of a year.

The new study, published in the journal Preventive Medicine, also found that having access to a smoking cessation program through their internet service provider was associated with a lower rate of smoking relapse.

“We found no evidence that the use of a cessation treatment by a patient would increase their chance of relapse,” said lead author Dr. Ravi K. Thakur of the University of Connecticut School of Medicine in Farmington. “This provides further support for treatment-as-usual to be included in comprehensive smoking cessation care.”

Treatment-as-usual, or TAU, is when a smoker just tells their doctor or nurse that they are trying to quit. Since 95 percent of smokers do not receive any tobacco-related treatment over the year, researchers compared odds of relapse among patients in two smoking cessation programs.

One was an online program with about 125,000 participants that provided minimal contact with patient and counselor, compared to the other, which had treatment available through the patient’s internet service provider.

Patients who had access to the online cessation program had a 50 percent lower rate of smoking relapse than those who had treatment available only through their internet service provider.

The study didn’t prove that the online treatment was more effective than other more intensive treatments, like medication or counseling with a therapist. But, the researchers point out that prior research on this topic has shown that such approaches are more effective than TAU.

“What’s unique about this report is that we provide a very high level of detail in terms of how many individuals were enrolled into the program, what the baseline characteristics were, and what success was like,” Kuehl said in a telephone interview.

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MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the regulation of gene expression through translational repression or through induction of mRNA degradation. They act on target mRNAs through base-pairing with partially complementary sequences. miRNAs are expressed in all life forms, they are well conserved across species, and they can control gene expression throughout the cell cycle. They are known to be involved in diverse biological processes including cellular growth, differentiation, apoptosis, signal transduction, cell cycle regulation, and stress response, as well as tumorigenesis. Some miRNAs are expressed in a tissue-specific manner and some have been implicated in organ transplantation. Recent work has shown that some miRNAs may be involved in the regulation of innate and adaptive immune responses. miRNAs are present in multiple circulating fluid and biomaterial samples, and they can be detected in plasma, serum, urine, saliva, ascites fluid, bone marrow, and tissue samples. Research has shown that miRNAs are associated with numerous cellular processes and dysregulation of the miRNAs can be associated with various diseases. More than 100 miRNAs have been identified in both human and animals to date. We will briefly review the structure and function of miRNAs and focus on the role of these small RNA molecules in transplantation.The present invention relates to a method and apparatus for polishing semiconductor wafers. In particular, the present invention relates to apparatus for polishing semiconductor wafers that exhibit an unacceptably large degree of surface non-uniformity.
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