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University Park Health System is committed to providing quality care for our patients. Whether you are a new patient or a returning patient, you will receive customized, compassionate care that is guided by the best in medical.
Michael Reese hospital is a full service general hospital with a rich tradition dating back to 1881. Our award-winning physicians and nurses deliver comprehensive specialty medical and surgical care and the very best in clinical care, diagnostics and research. We are one of the top-ranked hospitals in Chicago for orthopedics, cancer treatment, diabetes care, women’s health, urology and more. We consistently rank as one of the top 10 hospitals for total gastroenterology care in the United States.
University Park Health System’s Michael Reese Hospital is a regional medical referral and teaching center. Our focus is on patient care and advancing professional knowledge. We are committed to a “bottom-up” process in which our physicians and staff are involved in all aspects of medical care, research, and education. For further information please visit michaelreese.org.Microvascular Ischemia, Oxidative Stress, and Mitochondrial Damage in Patients With Ischemic Heart Disease.
Ischemic myocardium might be characterized by decreased perfusion and insufficient oxygen supply. Moreover, mitochondrial damage and oxidative stress are also present in ischemic myocardium. Under long-term ischemia, mitochondria might be damaged and have a reduced reserve capacity. The aim of this study was to assess the correlation of microvascular ischemia, oxidative stress, and mitochondrial damage with the ischemic heart disease (IHD) severity evaluated by echocardiography. The study included 32 patients with IHD and 32 healthy volunteers. Skin microvascular perfusion was assessed using laser speckle contrast analysis, and the levels of serum malondialdehyde, glutathione peroxidase, and superoxide dismutase-1 were determined by spectrophotometry. Two-dimensional echocardiography was performed to evaluate the left ventricular ejection fraction (LVEF) and left ventricular diastolic (E/A) and systolic (s) waves. Ultrasound Doppler imaging was used to measure the left ventricular isovolumetric relaxation time (IVRT). The microvascular perfusion and the E/A ratio decreased, whereas the IVRT and the IVRT/III ratio