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Tip For a more hands-on approach to learning how to use Photoshop, Microsoft offers a very approachable, step-by-step, and video tutorial-based approach to Photoshop in Windows 8 called Photo Story. See the box on Windows 8’s Photo Story. ## Windows 8’s Photo Story Windows 8 sports an impressive set of advanced photo editing tools that work like magic when applied to your photos. One such feature is Microsoft’s Photo Story technology, a hybrid of a number of tools that can help with photo editing. Photo Story comes with a number of different features, and you can access all of them using the three photo editing tools you’ve already seen in this chapter: The Pantone tool, a preset, and a custom-color palette. Photo Story works best if you’re on a Windows 8 laptop or tablet, so let’s take a look at how it works: 1. **Use the Photo Story editing tools**. Click the Photo Story icon (shown in Figure 3-8), hit the middle square of the three icons at the upper right corner of the screen, or press the keyboard shortcut Ctrl+M. In the menu that appears, choose the tool you want from the panel. The tools are color, tone, and exposure.
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Whether you want to edit an old photo or start from scratch, Photoshop Elements is built to cater to all your digital photo editing needs. Contents In this guide, you will find: Preview your photo Remove unwanted objects from your image and apply editing effects Add finishing touches to your photograph Change the exposure and brightness of an image Enhance details and fix imperfections Resize, crop, and rotate an image Adjust the contrast, color, saturation and clarity Brighten the image, and darken the shadows Black & white an image Highlight details and make colors pop Apply special effects We show you how to use each function, and show you how to work with the RAW file format, the Tiff and JPEG file formats, as well as the PC/MAC Windows toolbars and in Mac OS X. We’ll also explain the difference between the paid and the free versions of Photoshop Elements, and how much processing power they use. Setting Up Photoshop Elements Download the free version of Photoshop Elements from the Adobe website, or go to the website of the computer or operating system you’re using to download it. You should have a direct internet connection when you’re downloading Photoshop Elements. Edit a JPEG file in Photoshop Elements You can edit images in Photoshop Elements in the same way as you would edit a JPEG file in a copy of Photoshop. Install the software and launch Photoshop Elements Mac OS X Download the Photoshop Elements package and double-click the archive file to open it. There is a shortcut icon on your desktop when you first open the application. You can drag this icon to your Dock. The Photoshop Elements icon looks like a magic wand. Windows When you click the download link on the Adobe web site, it will download a file that you can open by double-clicking it. You can drag the Photoshop Elements shortcut to your Windows start bar. Open the program and launch Photoshop Elements Once it opens, you’ll see the Photoshop Elements Welcome screen. In Photoshop Elements Locate your image file and click it to select it. As it loads, you’ll see a preview of the image you have selected. If you’re happy with the image, use the zoom tool to magnify the preview so that you can see more detail. The two dots at the 05a79cecff
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Ikaros is a Kruppel-like zinc finger transcription factor that has been demonstrated to play a critical role in self-renewal of hematopoietic stem cells (HSCs), and its loss or mutation results in failure of proper establishment of HSC pool. While Ikaros has been reported to repress expression of certain other factors, such as CCAAT/enhancer binding protein beta (C/ebpbeta) and sclerotin, the target genes and mechanisms by which Ikaros regulates gene expression are not understood. Here we report that Ikaros represses beta-globin expression by inhibiting trans-activation of the gene by upstream E-box through protein-protein interaction with nuclear co-activator BCL11A, a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor. In addition, we identified three sites in the second intron of the Ikaros gene that are critical for its repression function. The two intronic sites (a-1 and a-2) are required for repression of the E-box luciferase reporter, and deletion of the site a-2 leads to a complete loss of E-box repression function. The a-2 site is a binding site for Ikaros, and we further demonstrated that the binding is inhibitory. Our data indicated that Ikaros represses beta-globin expression by binding to a-2 site in the second intron, and that this interaction disrupts the E-box binding to the upstream co-activator BCL11A, resulting in repression of the transcription activity of BCL11A. Furthermore, we found that Ikaros interacts with BCL11A through conserved R-box (RBP-1-like box) and zinc-finger motif in the N-terminal region of BCL11A. The presence of Ikaros is required for this interaction, and the Ikaros-BCL11A interaction is critical for Ikaros repression function. Together, we demonstrate that Ikaros cooperatively inhibits E-box mediated transcription through protein-protein interactions with BCL11A. Our study further demonstrates a new function of Ikaros in the regulation of hematopoiesis. Ikkaros is a Kruppel-like zinc finger transcription factor that has been demonstrated to play a critical role in self-renewal of hematopoietic stem
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The Content-Aware Fill tool makes it easy to fill in holes, missing or extra objects in a photograph. The blend mode can be applied to the filled areas. How to Get Started To get started with Photoshop, you must download a copy of Photoshop. The easiest way to download Photoshop is from the Adobe website. Once the installation is complete, check out the Photoshop Tutorials for many useful tutorials about Photoshop. If you are looking for something more advanced, you can get a copy of Photoshop CS5 from the Adobe website. Once you have installed Photoshop and check out the Photoshop Tutorials, you can try out the Auto-Tutorial feature to get started using Photoshop. The Auto-Tutorial feature is the best place to start learning the basics of Photoshop. To learn more about Photoshop, you can visit the Adobe Photoshop blog, which contains many tips and tricks for using Photoshop. Mathematics is the science of the quantities of our universe, it is the study of the quantities of all the things we can measure. It is a science because it will help us make sense of the world around us. Mathematics is the study of the how-to-do-things with numbers and symbols. Mathematics is essential for everything we do, it plays an important role in our society today. There are many interesting and complex mathematics concepts. Today, we will talk about the Pythagorean Theorem. It is a mathematical equation that is very popular in the computer and engineering fields. What is the Pythagorean Theorem? The Pythagorean Theorem is an equation used in two main applications: it gives us the formula to find the area of a triangle, and it gives us the formula to find the length of a side of a right triangle. For example, The Pythagorean Theorem tells us that the area of a square with side length $a$, base $b$, and hypotenuse $c$, equals $a^2+b^2$. The area of a triangle is found with the Pythagorean Theorem, which is a formula to find the area of a triangle. What is the Pythagorean Theorem? The Pythagorean Theorem is one of the most famous theorems in mathematics. It has many interesting applications. For instance, if you have a right triangle with angle $\theta$, you can use the Pythagorean Theorem to find out what the length of any
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Rift Rivals is a game that is compatible with PC and Mac. It will work on all Intel and AMD-based computers, including laptops. Each player needs a copy of Rift Rivals in order to play. NOTE: The Rift Rivals game engine will not run on Windows 10. Cloud storage is required in order to save game progress between matches. The game can be played on the Rift, or through a free browser version. Game Instructions: The goal of the game is to capture the five stone pieces and place them on the
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