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Plural selectivity in the somatostatin receptor-dependent cellular responses.
Somatostatin (SRIF) exerts pleiotropic effects in neurons by activation of the G-protein-coupled somatostatin receptor subtypes 5 (SSTR5), G(q) or G(i). The present study investigates the postsynaptic responses to SRIF-like peptides in chick spinal cord cultured neurons and in dorsal root ganglion (DRG) neurons derived from SSTR5-transgenic mice. Pertussis toxin (PTX)-sensitive increases in inositol phosphate formation, intracellular Ca(2+) concentration and the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) were only seen after activation of SSTR5 or the G(q)-pathway. On the contrary, in SSTR5-transgenic DRG neurons (SSTR5 +), all tested responses were potentiated by SRIF-14 and cortistatin (pIC(50) 7.9 and 7.8), but not Octreotide (pIC(50) 8.5). We conclude that, in neurons of the central nervous system, SRIF exerts selective actions through the activation of G(i)-signaling, the latter stimulating hyperpolarization of the postsynaptic membrane. The differential action between SSTR5 and SSTR5 + neurons, emphasizes the importance of defined somatostatin receptor subtypes for the physiological and pathological status of neurons.Measuring the water barrier in thin membranes by NMR.
The formation of a water layer near the lipid membrane surfaces, called the hydration layer, is a widely observed phenomenon in the solid and liquid phases, which is thought to be important in a variety of processes of biological interest. The time-dependent evolution of this layer, as imaged by NMR, is of interest not only for any functions that are related to this layer, but also because of its potential use as a means of controlling membrane flow. However, NMR measurements are usually carried out at low (approximately 1000 mG) magnetic fields and at temperatures that are
Download PLAB 1 notes swamy plain english Plab. This course is for advanced and 1st year students to prepare them for the government CLAT exam.
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SWAMI TALIBAN Sangeet Varidhi Daaaru (PLAB) 2nd year/ 3rd year/ 4th year / 5th year. By admin 26:36
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PLAB Notes for the Notes PLAB First year (For Any Graduate) plab notes swamy plab 1. Swami. PALLIATIVE CARE PDF FREE DOWNLOAD.
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Nov 30, 2016 · Dr. Khalid Jiwan Bajwa’s Notes for PLAB or PALLIATIVE CARE to be precise of UGC JEE not for the OCI for which a separate study material is required. Click here to download this Study Notes for All 4 Years/ 5th Year/ Third Year/ First Year of PLAB.
Plab study notes, (Plabule – 1st Plab, (Plaab – 2nd Plab, (Plaab – 3rd Plab. jt
What is PLAB?. UGC JEE CLAT is an entrance test to get admission in Indian Universities (12+2) and this is also a qualifying exam for Indian Foreign Service Examination.
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